Rejuran Polynucleotides for Dark Under-Eye Circles - Could This Be the Answer You've Been Looking For?

Dark circles. Hollow, crepey under-eyes. That permanently exhausted look no matter how well you slept. If you've tried every eye cream on the market and still aren't seeing results, you're not alone and you're not imagining it. The under-eye area is one of the most delicate and complex areas of the face to treat, and topical skincare can only go so far. That's where Rejuran Polynucleotides come in.

At Cheshire MediGlow in Altrincham, we're proud to offer Rejuran as part of our advanced polynucleotide treatments and for under-eye concerns specifically, it's fast becoming one of the most requested treatments we have.

So, What Is Rejuran?

Rejuran is a cutting-edge injectable skin booster that originated in South Korea, where it has been the leading polynucleotide treatment for over a decade. It's now CE-marked and available across the UK, and it works in a fundamentally different way to anything most people have tried before.

Rejuran contains polynucleotides (PN), highly purified DNA fragments derived from wild salmon. These fragments are biocompatible, meaning they work safely and naturally with human skin. Once injected, they act like repair signals inside the skin, triggering your own cells to regenerate, rebuild, and restore themselves from within.

This isn't about filling a space or adding volume. Rejuran is about improving the actual quality and health of your skin at a cellular level.

Why Is the Under-Eye Area So Tricky?

The skin beneath your eyes is some of the thinnest skin on your entire body, around 0.5mm compared to 2mm elsewhere on the face. It has fewer oil glands, less collagen support, and is in constant motion from blinking and facial expressions. Over time, this area loses moisture, elasticity, and thickness, leading to:

• Dark circles and discolouration

• A hollow or sunken appearance

• Fine lines and crepey texture

• Puffiness or under-eye bags

• A tired, dull look that doesn't reflect how you actually feel
  

Traditional solutions like eye creams, caffeine patches, and even hyaluronic acid skin boosters often fall short in this area because they don't address the root cause, the breakdown of the skin's cellular structure and its declining ability to repair itself.

How Does Rejuran Target the Under-Eye Area?

There is a specific formulation of Rejuran called Rejuran I (the "I" standing for eye), developed specifically for the delicate zone around the eyes. It's a lighter, more fluid formulation than standard Rejuran, making it ideal for injection into the ultra-thin under-eye skin without causing lumps or irregularities.

When Rejuran I is injected beneath the eyes, the polynucleotides get straight to work:

• Stimulates collagen and elastin production - Rejuran activates fibroblasts, the cells responsible for producing collagen and elastin. This helps thicken and strengthen the fragile under-eye skin over time, giving it more resilience and structure.

• Improves circulation - it supports the growth of new, healthy blood vessels in the area, which can visibly reduce that dark, bruised-looking shadow beneath the eyes.

• Deeply hydrates from within - the polynucleotides attract and retain moisture in the tissue, plumping the skin and reducing that hollow, crepey appearance.

• Calms inflammation - chronic low-level inflammation in the under-eye area can contribute to puffiness and discolouration. Rejuran's PDRN has natural anti-inflammatory properties that help stabilise and soothe the skin.
  

The result over a course of treatments is genuinely thicker, healthier, more hydrated under-eye skin, with reduced darkness, improved texture, and a more rested, refreshed appearance.

What Makes Rejuran Different From Tear Trough Filler?

This is one of the questions we get asked most. Tear trough filler (hyaluronic acid) and Rejuran polynucleotides are both used in the under-eye area, but they work completely differently and suit different concerns.

Tear trough filler adds volume to fill a hollow or sunken appearance under the eye. It's excellent when the main issue is volume loss, but it doesn't improve skin quality, and if the skin itself is thin or crepey, filler alone may not give the result you're hoping for.

Rejuran, on the other hand, doesn't add volume. It repairs and regenerates the skin itself, improving thickness, hydration, texture, and circulation. For dark circles caused by skin thinning, poor microcirculation, or loss of collagen, Rejuran is often far more appropriate.

Many patients benefit from both Rejuran to improve skin quality, and tear trough filler to address volume loss but during your consultation at Cheshire MediGlow, we'll assess your specific concerns and recommend the right approach for you.

What Results Can You Expect?

Rejuran is a progressive treatment. The results build over time, and the improvements continue developing even after your course is complete because your skin is actively regenerating.

Here's a general timeline of what to expect:

Days 3–5 after the first session - subtle improvements in hydration and plumpness begin to appear.

Weeks 2–4 - more noticeable improvements in skin texture and a reduction in crepiness under the eyes.

Weeks 8–12 - the strongest results become visible, as collagen remodelling continues and the skin becomes progressively thicker, smoother, and more even in tone.

Most patients require a course of 2–3 sessions, spaced 3–4 weeks apart, with results lasting around 6–9 months. Maintenance sessions once or twice a year help sustain the improvement.

Is Rejuran Safe?

Rejuran has been used clinically for over 10 years, with more than 15 million syringes used since its launch in 2014. It holds CE MDR certification (obtained in 2024) and is present in more than 50 countries worldwide, backed by 30 years of research in regenerative science.

The PDRN molecule is biocompatible — it works harmoniously with human tissue and has a well-established safety profile. Side effects are typically mild and short-lived: some redness, minor swelling, or small bumps at the injection points are normal immediately after treatment, and generally settle within 24–72 hours.

It is not suitable if you are pregnant or breastfeeding, have a known fish or seafood allergy, or have an active skin infection or inflammatory condition in the treatment area.

Who Is Rejuran Under-Eye Treatment Best For?

Rejuran I is an excellent option if you're experiencing:

• Dark circles that don't respond to skincare or sleep

• Crepey, fine-lined skin beneath the eyes

• A hollow or tired appearance around the eyes

• Loss of firmness and elasticity in the under-eye area

• Overall thinning of the skin in this zone
  

It's suitable for a wide range of ages and skin types, and because it works with your skin's own biology rather than adding a foreign substance, results look genuinely natural.

Frequently Asked Questions

Do Polynucleotides hurt? The under-eye area is sensitive, but topical anaesthetic cream is applied before treatment to keep you comfortable. Most patients describe the sensation as very manageable.

Is there downtime to Polynucleotides?

There's minimal downtime. You may notice some small bumps or mild redness in the under-eye area for 24–72 hours after treatment, but most clients feel comfortable returning to their normal routine the same day or the next morning.

How many sessions will I need?

We typically recommend a course of 2–3 sessions, spaced 3–4 weeks apart, for the best results. Some patients also choose to begin with a single session to see how their skin responds before committing to a full course.

Can Rejuran be combined with other treatments at Cheshire MediGlow?

Absolutely. Rejuran pairs beautifully with other treatments in our clinic, including PRP, polynucleotides for the full face, anti-wrinkle injections, and skin boosters. Our team will advise on the best combination and timing for your individual needs.

How long do results last?

Results typically last 6–9 months after completing a course, after which a maintenance session can reinvigorate the regenerative process. Many clients find that once or twice yearly keeps their under-eye area looking consistently refreshed.

Ready to Finally Address Those Dark Circles?

If you're tired of covering up with concealer and want to treat the cause rather than the symptom, Rejuran Polynucleotides could be the answer. Book a consultation with our team at Cheshire MediGlow in Altrincham and we'll assess your under-eye concerns and recommend the most appropriate treatment plan for you.

Book online or call us on 0161 706 2106.