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Polynucleotides
Polynucleotides are cutting-edge regenerative skin and hair treatments derived from highly purified DNA fragments. They work at a cellular level to stimulate tissue repair, reduce inflammation, and promote collagen and elastin production. Unlike traditional injectables, polynucleotides help restore and heal the skin from within, making them ideal for treating under-eye concerns, fine lines, scarring, dullness, and hair thinning.
What we offer
Discover the latest in regenerative aesthetics with Plinest® and Vitran polynucleotide injections, clinically proven, CE-marked treatments designed to repair, hydrate, and rejuvenate skin and scalp.
Plinest, developed by Mastelli (the original pioneers of polynucleotide technology), uses ultra-purified trout DNA to stimulate collagen, reduce inflammation, and restore skin integrity, ideal for concerns like fine lines, under-eye hollowness, acne scarring, and hair loss.
At Cheshire MediGlow, we also offer Vitran by Vitralife, a next-generation polynucleotide treatment made from filtered salmon DNA with high molecular weight for deep cellular repair, hydration, and long-lasting skin regeneration.
Backed by research and widely trusted across Europe, both options offer safe, natural-looking results for those seeking non-invasive rejuvenation.
How do Polynucleotides work?
Polynucleotides work by stimulating fibroblast and dermal papilla activity, promoting angiogenesis (formation of new blood vessels) and reducing oxidative stress creating an ideal environment for healthy hair follicles. Clinical research published in Dermatologic Therapy and Journal of Cosmetic Dermatology has shown that injectable PN therapy leads to measurable improvements in hair density, scalp health, and follicular vitality. In one study, participants experienced a significant increase in hair thickness and density after just 3–4 sessions, with minimal side effects and high tolerability.
This makes polynucleotide therapy an excellent option for menopausal women, stress-related hair loss, and individuals seeking a drug-free, regenerative approach to scalp restoration. It can also be used in combination with PRP, exosomes, or LLLT for comprehensive, multi-layered hair regrowth protocols.
Exosomes are packed with repair signals that directly target the hair bulb. When microneedled into the scalp, they stimulate blood circulation, reduce follicle shrinkage, and encourage new hair growth. This makes them ideal for androgenetic alopecia (pattern baldness), hormonal thinning, and general hair rejuvenation—without the side effects of hormone-based treatments
Polynucleotide for Hair Growth
Polynucleotides aren’t just for skin, they’re transforming hair restoration too. When injected or microneedled into the scalp, Plinest:
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Improves blood flow to dormant follicles
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Calms micro-inflammation linked to androgenetic alopecia
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Prolongs the anagen phase, reducing excessive shedding
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Strengthens the scalp barrier for healthier, thicker strands
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Ideal for men and women in the early to moderate stages of hair loss, or as a maintenance therapy alongside PRP or exosomes.
Who Is suitable for Polynucleotides?
Polynucleotide (PN) therapy, such as Plinest® for Hair, is suitable for men and women experiencing thinning, brittle hair, or early-stage androgenetic alopecia. It is particularly beneficial for individuals with scalp inflammation, hormonal imbalance, or poor follicle microcirculation, all of which can impair hair growth. Peri- and post-menopausal women often respond well to polynucleotide treatment, as the regenerative properties of PN help counteract hormonal thinning by improving tissue quality, increasing vascular support, and extending the hair growth cycle.
Face Treatment Benefits
Discover the benefits by concern below. Patients notice renewed luminosity, refined pores and a plumper complexion after a course of three sessions, spaced three to four weeks apart.
Concern | Result |
|---|---|
Fine lines & wrinkles | Firmer, smoother skin texture |
Acne scars & enlarged pores | Progressive dermal remodelling |
Redness & sensitivity | Anti-inflammatory repair and barrier support |
Loss of elasticity | Visible tightening and improved bounce |
Who Is suitable for Polynucleotide Facial & Under-Eye Treatment?
Polynucleotide treatments using either Pilnest’s medical-grade formulations or Vitaran evidence-based formula are ideal for individuals experiencing early signs of ageing, dull or dehydrated skin, or under-eye hollowness and dark circles. This regenerative treatment is suitable for a wide range of skin types, including sensitive, mature, or compromised skin, and is especially beneficial for those who may not be ready for dermal fillers but are seeking natural skin revitalisation. It is a safe and effective choice for men and women, including those in their 30s to 60s, and is particularly popular among peri- and post-menopausal women experiencing collagen decline and volume loss. Polynucleotides gently stimulate fibroblasts, hydrate the skin, and improve tone and elasticity, making them perfect for rejuvenating delicate areas like the under-eyes while promoting long-term skin regeneration.