Rejuran Polynucleotides - The Viral Korean Skin Regeneration Treatment

The Korean aesthetic industry is known worldwide for its innovative, skin-first approach to anti-ageing and skin health. One treatment currently gaining global attention is Rejuran Polynucleotides, often referred to as the “Korean skin healer” or “salmon DNA facial”.

At Cheshire MediGlow, we are passionate about advanced regenerative treatments that improve skin quality from within. In this blog, we explore what Rejuran Polynucleotides are, why they have become such a viral treatment, and who they are most suitable for.

What Are Rejuran Polynucleotides?

Rejuran is an injectable skin treatment made from polynucleotides (PN) – highly purified DNA fragments derived from salmon. While this may sound unusual, salmon DNA is extremely compatible with human skin and has powerful regenerative and healing properties. Unlike traditional fillers that focus mainly on restoring volume, Rejuran works by repairing damaged skin cells, improving elasticity, and strengthening the skin barrier. It is widely used across South Korea, where the focus is on achieving naturally healthy, radiant, glass-like skin rather than altering facial structure.

Why Has Rejuran Become So Popular?

Korean skincare and aesthetic treatments are globally recognised for prioritising long-term skin health and prevention. Rejuran fits perfectly into this philosophy.

The treatment has become viral due to its ability to:

• Improve overall skin quality

• Reduce fine lines and early ageing

• Strengthen fragile or damaged skin

• Improve hydration and elasticity

• Reduce inflammation and redness

• Support acne scar and skin repair

Rather than simply filling wrinkles, Rejuran aims to restore skin function at a cellular level.

How Do Polynucleotides Work?

Polynucleotides stimulate the skin’s natural healing response. Once injected, they work by:

• Encouraging fibroblast activity (cells responsible for collagen production)

• Improving skin thickness and strength

• Enhancing tissue repair

• Increasing hydration retention

• Reducing inflammation

Over time, this leads to healthier, smoother, and more resilient skin. Results develop gradually, meaning improvements look extremely natural and continue to improve after treatment.

What Skin Concerns Can Rejuran Treat?

Rejuran is a versatile regenerative treatment and is commonly used to improve:

• Fine lines and wrinkles

• Dull or tired-looking skin

• Thin or crepey skin

• Acne scarring

• Enlarged pores

• Redness and inflammation

• Under-eye skin quality and dark circles

• Sun-damaged or ageing skin

It is particularly effective for patients who want skin rejuvenation without adding volume.

Rejuran vs PRP/PRF Treatments

Rejuran is often compared to regenerative treatments such as PRP and PRF.

Rejuran

• Uses purified polynucleotides

• Strong focus on tissue repair and inflammation reduction

• Excellent for delicate and damaged skin

PRP / PRF

• Derived from your own blood

• Stimulates growth factors and collagen production

• Offers natural regenerative skin improvement

Both are excellent options, and the best choice depends on individual skin concerns and treatment goals.

What Areas Can Be Treated?

Rejuran can be used on multiple areas including:

• Full face rejuvenation

• Under-eye area

• Neck and décolletage

• Hands

• Acne scar-prone areas

The treatment is especially popular for improving delicate or difficult-to-treat skin areas.

What Happens During Treatment?

Treatment involves multiple micro-injections placed into the skin using advanced injection techniques.

Treatment Overview:

• Consultation and skin assessment

• Numbing cream applied for comfort

• Carefully placed injections into targeted areas

• Treatment typically takes 30–45 minutes

Some mild swelling or small bumps can occur immediately after treatment, which usually settles within a few days.

How Many Treatments Are Needed?

For optimal results, Rejuran is usually performed as a course of treatments.

Typical recommendation:

• 3 sessions spaced approximately 3–4 weeks apart

• Maintenance treatments every 6–12 months

Skin quality improvements continue developing over time as collagen and tissue repair increase.

Who Is Suitable for Rejuran?

Rejuran is ideal for patients who:

• Want natural skin rejuvenation

• Have early signs of ageing

• Experience dull or damaged skin

• Have sensitive or thin skin

• Prefer regenerative treatments

• Want to improve under-eye skin quality

It is suitable for a wide range of ages and skin types.

Why Choose Cheshire MediGlow for Rejuran Treatment?

At Cheshire MediGlow, patient safety and natural results are always our priority. We specialise in regenerative aesthetic treatments designed to improve skin health while maintaining natural beauty.

Every treatment begins with a comprehensive consultation to ensure your treatment plan is tailored specifically to your skin, concerns, and long-term goals.

Rejuran Polynucleotides represent the next generation of aesthetic treatments, focusing on repairing and strengthening the skin rather than simply masking signs of ageing. As Korean regenerative treatments continue to influence global aesthetics, Rejuran has become one of the most exciting innovations for patients seeking radiant, healthy, youthful-looking skin.

Book Your Consultation

If you would like to learn more about Rejuran Polynucleotides or explore whether this treatment is right for you, please get in touch.